The Effect of APOE on Dementia through Multiple Pathologies Note: An Official Proposal has not been Submitted to NACC. Lead Investigator: Fan Xia Institution : NACC E-Mail : fanxia@uw.edu Proposal ID : 1752 Proposal Description: Estimate the direct effect of APOE on cognitive impairment and the indirect effect mediated through multiple pathologies, including cerebrovascular disease, cardiovascular disease, ADNC, Lewy body, and TDP-43. The datasets I will be needing are UDS and NP in the CSV format.